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Article

Amygdala dysfunction in men with the fragile X premutation.

Brain : a journal of neurology - 1 Feb 2007

Hessl David, Rivera Susan, Koldewyn Kami, Cordeiro Lisa, Adams John, Tassone Flora, Hagerman Paul J, Hagerman Randi J

Abstract excerpt

Premutation alleles (55-200 CGG repeats) of the fragile X mental retardation 1 (FMR1) gene are associated with autism spectrum disorder in childhood, premature ovarian failure, and the neurodegenerative disorder, fragile X-associated tremor/ataxia syndrome (FXTAS). FXTAS, and perhaps the other clinical presentations among carriers, are thought to be due to toxic gain-of-function of elevated levels of the...

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Source

Identifiers

PMID: 17166860
DOI: 10.1093/brain/awl338

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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