Article
Abnormal elevation of FMR1 mRNA is associated with psychological symptoms in individuals with the fragile X premutation.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Nov 2005
Hessl David, Tassone Flora, Loesch Danuta Z, Berry-Kravis Elizabeth, Leehey Maureen A, Gane Louise W, Barbato Ingrid, Rice Cathlin, Gould Emma, Hall Deborah A, Grigsby James, Wegelin Jacob A, Harris Susan, Lewin Foster, Weinberg Dahlia, Hagerman Paul J, Hagerman Randi J
Abstract excerpt
Until recently, individuals with premutation alleles (55-200 CGG repeats) of the fragile X mental retardation 1 (FMR1) gene were believed to be psychologically unaffected. However, the recent documentation of abnormal elevation of FMR1 mRNA, discovery of fragile X-associated tremor/ataxia syndrome (FXTAS), and reports of psychiatric disorders in children and adults with the premutation have suggested a pathogenic...
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