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Article

Brain structure and intragenic DNA methylation are correlated, and predict executive dysfunction in fragile X premutation females.

Translational psychiatry - 13 Dec 2016

Shelton A L, Cornish K M, Kolbe S, Clough M, Slater H R, Li X, Kraan C M, Bui Q M, Godler D E, Fielding J

Abstract excerpt

DNA methylation of the Fragile X mental retardation 1 (FMR1) exon 1/intron 1 boundary has been associated with executive dysfunction in female carriers of a FMR1 premutation (PM: 55-199 CGG repeats), whereas neuroanatomical changes have been associated with executive dysfunction in PM males. To our knowledge, this study for the first time examined the inter-relationships between executive function,...

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Source

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Identifiers

PMID: 27959330
DOI: 10.1038/tp.2016.250
PMCID: PMC5290342

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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