Article
Psychological symptoms correlate with reduced hippocampal volume in fragile X premutation carriers.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Apr 2010
Adams P E, Adams J S, Nguyen D V, Hessl D, Brunberg J A, Tassone F, Zhang W, Koldewyn K, Rivera S M, Grigsby J, Zhang L, Decarli C, Hagerman P J, Hagerman R J
Abstract excerpt
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder occurring in male and occasional female carriers of a premutation expansion (55-200 CGG repeats) of the fragile X mental retardation 1 gene (FMR1). This study assessed the relationship between hippocampal volume and psychological symptoms in carriers, both with and without FXTAS, and controls. Volumetric MRI measures, clinical...
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