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Article

Psychological status in female carriers of premutation FMR1 allele showing a complex relationship with the size of CGG expansion.

Clinical genetics - 1 Feb 2015

Loesch D Z, Bui M Q, Hammersley E, Schneider A, Storey E, Stimpson P, Burgess T, Francis D, Slater H, Tassone F, Hagerman R J, Hessl D

Abstract excerpt

We utilized a sample of 299 adult females aged between 19 and 86 years, carrying fragile X mental retardation (FMR1) alleles with small CCG expansions ranging from 50 to 141 repeats to analyse the relationships between psychological symptoms as assessed by the Symptom Checklist-90-Revised (SCL-90-R) and the size of the CGG repeat in the FMR1 gene. There were highly significant (negative) correlations between the...

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Source

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Identifiers

PMID: 24428240
DOI: 10.1111/cge.12347
PMCID: PMC4115039

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Psychological status in female carriers of premutation FMR1 allele showing a complex relationship with the size of CGG expansion.PMID 24428240Read ↗

Abnormal elevation of FMR1 mRNA is associated with psychological symptoms in individuals with the fragile X premutation.Semantic proximity Read ↗

Neurobehavioral phenotype in carriers of the fragile X premutation.Semantic proximity Read ↗

Differential sensitivity to life stress in FMR1 premutation carrier mothers of children with fragile X syndrome.Semantic proximity Read ↗

A deletion of 1.6 Kb proximal to the CGG repeat of the FMR1 gene causes fragile X-like psychological features.Semantic proximity Read ↗

Reduction in the number of CGG repeats on the FMR1 gene in carriers of genetic disorders versus noncarriers.Semantic proximity Read ↗

Examination of FMR1 transcript and protein levels among 74 premutation carriers.Semantic proximity Read ↗

FMR1 allele frequencies in 51,000 newborns: a large-scale population study in China.Semantic proximity Read ↗

Clinical implications of somatic allele expansion in female FMR1 premutation carriers.Semantic proximity Read ↗

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A female compound heterozygote (pre- and full mutation) for the CGG FMR1 expansion.Semantic proximity Read ↗

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