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Article

miR-10a overexpression is associated with NPM1 mutations and MDM4 downregulation in intermediate-risk acute myeloid leukemia.

Experimental hematology - 1 Oct 2011

Ovcharenko Dmitriy, Stölzel Friedrich, Poitz David, Fierro Fernando, Schaich Markus, Neubauer Andreas, Kelnar Kevin, Davison Timothy, Müller-Tidow Carsten, Thiede Christian, Bornhäuser Martin, Ehninger Gerhard, Brown David, Illmer Thomas

Abstract excerpt

OBJECTIVE: The study investigated differential microRNA (miRNA) expression patterns in acute myeloid leukemia (AML) patients with intermediate-risk (IR) characteristics. After characterization and validation of miR-10a, which was specifically upregulated in nucleophosmin 1 (NPM1) mutant AML samples, functional consequences of miR-10a overexpression were further delineated in vitro. MATERIALS AND METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21784052
DOI: 10.1016/j.exphem.2011.07.008

Genes

NPM1
MDM4

Provenance

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