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Article

Implications of the miR-10 family in chemotherapy response of NPM1-mutated AML.

Blood - 10 Apr 2014

Havelange Violaine, Ranganathan Parvathi, Geyer Susan, Nicolet Deedra, Huang Xiaomeng, Yu Xueyan, Volinia Stefano, Kornblau Steven M, Andreeff Michael, Croce Carlo M, Marcucci Guido, Bloomfield Clara D, Garzon Ramiro

Abstract excerpt

Nucleophosmin-mutated acute myeloid leukemia (NPM1mut-AML) patients have a high rate of complete remission (CR) to induction chemotherapy. However, the mechanisms responsible for such effects are unknown. Because miR-10 family members are expressed at high levels in NPM1mut-AML, we evaluated whether these microRNAs could predict chemotherapy response in AML. We found that high baseline miR-10 family expression in...

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Share to Antineoplastic Agents
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

Share to Membrane Glycoproteins

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Source

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Identifiers

PMID: 24596420
DOI: 10.1182/blood-2013-10-532374
PMCID: PMC3983615

Genes

NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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