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Article

Micro-RNAs and copy number changes: new levels of gene regulation in acute myeloid leukemia.

Chemico-biological interactions - 19 Mar 2010

Larson Richard A

Abstract excerpt

Alkylating agents, topoisomerase II inhibitors, ionizing radiation, and other hematotoxins induce DNA damage in hematopoietic stem cells that results in lesions such as balanced and unbalanced chromosome rearrangements, -5/del(5q) and/or -7/del(7q), as well as other submicroscopic genetic lesions. Together with epigenetic alterations, these result in dysplasia, clonal expansion, and ultimately myeloid leukemia....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19822134
DOI: 10.1016/j.cbi.2009.10.002
PMCID: PMC2846194

Genes

NPM1
FLT3
BAALC
ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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