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Comparative transcriptome analysis to unveil genes affecting recombinant protein productivity in mammalian cells

22 Jul 2008

Abstract excerpt

Low temperature culture (33 degrees C) has been shown to enhance the specific productivity of recombinant antibodies in Chinese hamster ovary (CHO) cells but did not affect antibody productivity in hybridoma (MAK) cells. We probed the transcriptional response of both cells undergoing temperature shift using cDNA microarrays. Among the orthologous gene probes, common trends in the expression changes between CHO...

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PMID: 18726962
DOI: 10.1002/bit.22039

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