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Article

The mitochondrial electron transport chain is dispensable for proliferation and differentiation of epidermal progenitor cells.

Stem cells (Dayton, Ohio) - 1 Sept 2011

Baris Olivier R, Klose Anke, Kloepper Jennifer E, Weiland Daniela, Neuhaus Johannes F G, Schauen Matthias, Wille Anna, Müller Alexander, Merkwirth Carsten, Langer Thomas, Larsson Nils-Göran, Krieg Thomas, Tobin Desmond J, Paus Ralf, Wiesner Rudolf J

Abstract excerpt

Tissue stem cells and germ line or embryonic stem cells were shown to have reduced oxidative metabolism, which was proposed to be an adaptive mechanism to reduce damage accumulation caused by reactive oxygen species. However, an alternate explanation is that stem cells are less dependent on specialized cytoplasmic functions compared with differentiated cells, therefore, having a high nuclear-to-cytoplasmic volume...

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Identifiers

PMID: 21780252
DOI: 10.1002/stem.695

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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