Article
A role for keratins in supporting mitochondrial organization and function in skin keratinocytes.
Molecular biology of the cell - 15 May 2020
Steen Kaylee, Chen Desu, Wang Fengrong, Majumdar Ritankar, Chen Song, Kumar Surinder, Lombard David B, Weigert Roberto, Zieman Abigail G, Parent Carole A, Coulombe Pierre A
Abstract excerpt
Mitochondria fulfill essential roles in ATP production, metabolic regulation, calcium signaling, generation of reactive oxygen species (ROS), and additional determinants of cellular health. Recent studies have highlighted a role for mitochondria during cell differentiation, including in skin epidermis. The observation of oxidative stress in keratinocytes from Krt16 null mouse skin, a model for pachyonychia...
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