Prospects for personalized medicine with inhibitors targeting the RAS and PI3K pathways.

doi:10.1586/erm.09.78

Back to search

Article

Prospects for personalized medicine with inhibitors targeting the RAS and PI3K pathways.

Expert review of molecular diagnostics - 1 Jan 2010

Lackner Mark R

Abstract excerpt

Tumor genetic analyses have revealed that the signaling pathways regulated by PI3K and RAS are of fundamental importance in a wide variety of human neoplasms, leading to intensive efforts to develop therapeutics that block signaling through these two key pathways. Both pathways frequently undergo...

Topics

Antineoplastic Agents
Biomarkers, Tumor
Enzyme Inhibitors
Humans
Mutation
Neoplasms
Phosphatidylinositol 3-Kinases
Phosphoinositide-3 Kinase Inhibitors
Precision Medicine
Signal Transduction
ras Proteins

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.