Article
An intronic variant in the GRP78, a stress-associated gene, improves prediction for liver cirrhosis in persistent HBV carriers.
PloS one - 1 Jan 2011
Zhu Xiao, Chen Lianzhou, Fan Wenguo, Lin Marie C M, Tian Linwei, Wang Min, Lin Sheng, Wang Zifeng, Zhang Jinfang, Wang Jinlong, Yao Hong, Kung Hsiangfu, Li Dongpei
Abstract excerpt
BACKGROUND: Our previous study indicated that a common variant (rs430397 G>A) in the intron 5 of glucose-regulated protein 78 (GRP78) gene was associated with risk and prognosis of primary hepatocellular carcinoma (HCC), including HBV- and cirrhosis-related HCC. rs430397 polymorphism may be a contributing factor or biomarker of HBV infection or HBV-related cirrhosis. METHODOLOGY/PRINCIPAL FINDINGS: 539...
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