Article
Lack of association between the GRP78 polymorphisms in the promoter and 3' UTR and susceptibility to chronic HBV infection in a Chinese Han population.
BMC medical genetics - 2 Jun 2010
Zhu Xiao, Li Dong-Pei, Fan Wen-Guo, Lin Marie C M, Wang Jin-Long, Lin Sheng-Qu, Huang Jian-Qing, Kung Hsiang-Fu
Abstract excerpt
BACKGROUND: Hepatitis B virus (HBV) infection causes large amount of unfolding or false-folding protein accumulation in the endoplasmic reticulum (ER), which in turn induces the expression of glucose-regulated protein 78 (GRP78). The aim in the present study was to analyse the potential association between GRP78 single-nucleotide polymorphisms (SNPs) and the risk of HBV infection. METHODS: The associations...
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