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Article

Wild-Type and rtA181T/sW172* Mutant Strains of Hepatitis B Virus Drive Hepatocarcinogenesis via Distinct GRP78-Mediated ER Stress Pathways.

Journal of medical virology - 1 Jan 2025

Liu Miao, Yuan Man, Ma Yuanji, Wang Jiayi, Cheng Xing, Shi Ying, Shang Jin, He Min, Bai Lang, Du Lingyao, Tang Hong

Abstract excerpt

Glucose-regulated protein 78 kDa (GRP78), a key marker of endoplasmic reticulum stress (ERS), is upregulated in hepatocellular carcinoma (HCC) tissues, but its role in hepatitis B virus (HBV)-induced tumorigenesis remains unclear. This study aimed to investigate the contribution of GRP78 to HBV-associated tumor development and explore the ERS pathways involved. The results showed that increased GRP78 expression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39749680
DOI: 10.1002/jmv.70151

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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