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Article

GRP78 promoter polymorphism rs391957 as potential predictor for clinical outcome in gastric and colorectal cancer patients.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Nov 2011

Winder T, Bohanes P, Zhang W, Yang D, Power D G, Ning Y, Gerger A, Wilson P M, Tang L H, Shah M, Lee A S, Lenz H-J

Abstract excerpt

BACKGROUND: Recently, the analysis of gastric and colorectal tumor specimens determined that 78-kiloDalton glucose-regulated protein (GRP78), an endoplasmic reticulum chaperone, up-regulation serves as an efficient mechanism protecting cells against apoptosis and can confer drug resistance. We tested whether functional polymorphisms within the GRP78 gene are related to clinical outcome in gastric and colorectal...

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Identifiers

PMID: 21382870
DOI: 10.1093/annonc/mdq771
PMCID: PMC3200220

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