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Article

Induction of type I interferon signaling by Pseudomonas aeruginosa is diminished in cystic fibrosis epithelial cells.

American journal of respiratory cell and molecular biology - 1 Jan 2012

Parker Dane, Cohen Taylor S, Alhede Morten, Harfenist Bryan S, Martin Francis J, Prince Alice

Abstract excerpt

The clinical manifestations of infection in cystic fibrosis (CF) are restricted to the lung, and involve a limited number of pathogens, suggesting a specific defect in mucosal immunity. We postulated that cystic fibrosis transmembrane conductance regulator (CTFR) mutations could affect the activation of type I interferon signaling in airway epithelial cells, which function in immune surveillance and initiate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21778412
DOI: 10.1165/rcmb.2011-0080OC
PMCID: PMC3262660

Genes

CFTR
STAT1
TBK1
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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