Association between VHL single nucleotide polymorphism (rs779805) and the susceptibility to prostate cancer in Chinese.

doi:10.1089/dna.2011.1408

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Association between VHL single nucleotide polymorphism (rs779805) and the susceptibility to prostate cancer in Chinese.

DNA and cell biology - 1 May 2012

Chen Jiawei, Wu Yilong, Shao Pengfei, Cao Qiang, Qin Chao, Li Pu, Ding Qi, Zhu Jian, Wang Meilin, Zhang Zhengdong, Li Jie, Yin Changjun

Abstract excerpt

The Von Hippel-Lindau (VHL) tumor suppressor gene is a crucial regulator of the hypoxia response pathway and plays an important role in tumorigenesis, particularly in tumor growth and vascularization. We hypothesize that polymorphisms in the functional region of VHL may influence susceptibility to prostate cancer (PCa). We genotyped a potentially functional polymorphism (rs779805) in 5' UTR region of VHL in a...

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PMID: 22084938
DOI: 10.1089/dna.2011.1408

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