Article
Mesenchymal stem cells promote the sustained expression of CD69 on activated T lymphocytes: roles of canonical and non-canonical NF-κB signalling.
Journal of cellular and molecular medicine - 1 Jun 2012
Saldanha-Araujo Felipe, Haddad Rodrigo, Farias Kelen C R Malmegrim de, Souza Alessandra de Paula Alves, Palma Patrícia V, Araujo Amélia G, Orellana Maristela D, Voltarelli Julio C, Covas Dimas T, Zago Marco A, Panepucci Rodrigo A
Abstract excerpt
Mesenchymal stem cells (MSCs) are known to induce the conversion of activated T cells into regulatory T cells in vitro. The marker CD69 is a target of canonical nuclear factor kappa-B (NF-κB) signalling and is transiently expressed upon activation; however, stable CD69 expression defines cells with immunoregulatory properties. Given its enormous therapeutic potential, we explored the molecular mechanisms...
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