Article
Expression of the leukocyte early activation antigen CD69 is regulated by the transcription factor AP-1.
Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 1997
Castellanos M C, Muñoz C, Montoya M C, Lara-Pezzi E, López-Cabrera M, de Landázuri M O
Abstract excerpt
The leukocyte Ag CD69, one of the earliest cell surface activation Ags, is up-regulated at the transcriptional level by proinflammatory stimuli involving the NF-kappaB/Rel family of transcription factors. However, promoter fragments lacking a critical kappaB motif respond to other stimuli such as phorbol esters and triggering Abs against TCR/CD3. Since the 5' promoter flanking region of the CD69 gene contains...
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