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CD69 Blockade Restores the Bone Marrow Niche and Delays Leukemogenesis in a Mouse Model of NrasG12D-driven Chronic Myelomonocytic Leukemia

2025-12-13

Abstract excerpt

<title>Abstract</title> <p> A subset of patients with chronic myelomonocytic leukemia (CMML) carry <italic>NRAS</italic> mutations, which are associated with shorter overall survival and higher risk of leukemic transformation. The precise impact of <italic>NRAS</italic> mutations on the bone marrow microenvironment (BME) remains unclear. In a mouse model of CMML induced by a single <italic>Nras</italic> <s...

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Literature Corpus work
737b1a38-576a-5f14-97e4-19e580832818
DOI
10.21203/rs.3.rs-8277899/v1
Open publication

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CD69 Blockade Restores the Bone Marrow Niche and Delays Leukemogenesis in a Mouse Model of NrasG12D-driven Chronic Myelomonocytic LeukemiaDOI 10.21203/rs.3.rs-8277899/v1
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