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Human umbilical cord-derived mesenchymal stem cells protect against experimental colitis via CD5+ B regulatory cells

11 Aug 2016

Abstract excerpt

BACKGROUND: To clarify the effect of human umbilical cord-derived mesenchymal stem cell (hUC-MSCs) treatment on colitis and to explore the role of CD5(+) B cells in MSC therapy. METHODS: The trinitrobenzenesulfonic acid (TNBS)-induced colitis mouse model was used. HUC-MSCs were transferred peritoneally. Survival rates, colitis symptoms, and macroscopic and histologic scores were evaluated. CD4(+) T helper (Th)...

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PMID: 27515534
DOI: 10.1186/s13287-016-0376-2

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