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Article

Motoneurons derived from induced pluripotent stem cells develop mature phenotypes typical of endogenous spinal motoneurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 21 Jan 2015

Toma Jeremy S, Shettar Basavaraj C, Chipman Peter H, Pinto Devanand M, Borowska Joanna P, Ichida Justin K, Fawcett James P, Zhang Ying, Eggan Kevin, Rafuse Victor F

Abstract excerpt

Induced pluripotent cell-derived motoneurons (iPSCMNs) are sought for use in cell replacement therapies and treatment strategies for motoneuron diseases such as amyotrophic lateral sclerosis (ALS). However, much remains unknown about the physiological properties of iPSCMNs and how they compare with endogenous spinal motoneurons or embryonic stem cell-derived motoneurons (ESCMNs). In the present study, we first...

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Identifiers

PMID: 25609642
DOI: 10.1523/JNEUROSCI.2126-14.2015
PMCID: PMC4402330

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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