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Efficient Differentiation of Mouse Embryonic Stem Cells into Motor Neurons

9 Jun 2012

Abstract excerpt

Direct differentiation of embryonic stem (ES) cells into functional motor neurons represents a promising resource to study disease mechanisms, to screen new drug compounds, and to develop new therapies for motor neuron diseases such as spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS). Many current protocols use a combination of retinoic acid (RA) and sonic hedgehog (Shh) to differentiate...

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PMID: 22711008
DOI: 10.3791/3813

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