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Simple Derivation of Spinal Motor Neurons from ESCs/iPSCs Using Sendai Virus Vectors

10 Jan 2017

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a progressive and fatal degenerative disorder of motor neurons (MNs). Embryonic stem cells (ESCs)/induced pluripotent stem cells (iPSCs) now help us to understand the pathomechanisms of ALS via disease modeling. Various methods to differentiate ESCs/iPSCs into MNs by the addition of signaling molecules have been reported. However, classical methods require multiple steps,...

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PMID: 28344997
DOI: 10.1016/j.omtm.2016.12.007

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