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Article

Histone fold modifications control nucleosome unwrapping and disassembly.

Proceedings of the National Academy of Sciences of the United States of America - 2 Aug 2011

Simon Marek, North Justin A, Shimko John C, Forties Robert A, Ferdinand Michelle B, Manohar Mridula, Zhang Meng, Fishel Richard, Ottesen Jennifer J, Poirier Michael G

Abstract excerpt

Nucleosomes are stable DNA-histone protein complexes that must be unwrapped and disassembled for genome expression, replication, and repair. Histone posttranslational modifications (PTMs) are major regulatory factors of these nucleosome structural changes, but the molecular mechanisms associated with PTM function remains poorly understood. Here we demonstrate that histone PTMs within distinct structured regions...

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Identifiers

PMID: 21768347
DOI: 10.1073/pnas.1106264108
PMCID: PMC3150920

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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