Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Out-of-frame T cell receptor beta transcripts are eliminated by multiple pathways in vivo.

PloS one - 1 Jan 2011

Mahowald Grace K, Mahowald Michael A, Moon Clara, Khor Bernard, Sleckman Barry P

Abstract excerpt

Non-productive antigen receptor genes with frame shifts generated during the assembly of these genes are found in many mature lymphocytes. Transcripts from these genes have premature termination codons (PTCs) and could encode truncated proteins if they are not either inactivated or destroyed by nonsense-mediated decay (NMD). In mammalian cells, NMD can be activated by pathways that rely on the presence of an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Codon, Nonsense
Share to Mice

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Reading Frames

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to RNA, Messenger

Share to RNA Stability

Share to T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 21765899
DOI: 10.1371/journal.pone.0021627
PMCID: PMC3135592

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Out-of-frame T cell receptor beta transcripts are eliminated by multiple pathways in vivo.PMID 21765899Read ↗

A Quality Control Pathway That Down-regulates Aberrant T-cell Receptor (TCR) Transcripts by a Mechanism Requiring UPF2 and TranslationSemantic proximity Read ↗

Frame-disrupting mutations elicit pre-mRNA accumulation independently of frame disruption.Semantic proximity Read ↗

RNA splicing promotes translation and RNA surveillance.Semantic proximity Read ↗

Protein tyrosine kinase p56lck controls allelic exclusion of T-cell receptor beta-chain genes.Semantic proximity Read ↗

Low cytoplasmic mRNA levels of immunoglobulin kappa light chain genes containing nonsense codons correlate with inefficient splicing.Semantic proximity Read ↗

Regulation of T cell receptor (TCR)-beta locus allelic exclusion and initiation of TCR-alpha locus rearrangement in immature thymocytes by signaling through the CD3 complex.Semantic proximity Read ↗

Exit of the pre-TCR from the ER/cis-Golgi is necessary for signaling differentiation, proliferation, and allelic exclusion in immature thymocytes.Semantic proximity Read ↗

TCRbeta transmembrane tyrosines are required for pre-TCR function.Semantic proximity Read ↗

Equal transcription rates of productively and nonproductively rearranged immunoglobulin mu heavy chain alleles in a pro-B cell line.Semantic proximity Read ↗

Transcripts from a novel BMPR2 termination mutation escape nonsense mediated decay by downstream translation re-initiation: implications for treating pulmonary hypertension.Semantic proximity Read ↗

Duality of enhancer functioning mode revealed in a reduced TCR beta gene enhancer knockin mouse model.Semantic proximity Read ↗

Posttranscriptional silencing of VbetaDJbetaCbeta genes contributes to TCRbeta allelic exclusion in mammalian lymphocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.