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RasGrf1: genomic imprinting, VSELs, and aging

11 Jul 2011

Abstract excerpt

Increase in life span in RasGrf1-deficient mice revealed that RasGrf1 deficiency promotes longevity. Interestingly, RasGrf1 is one of parentally imprinted genes transcribed from paternally-derived chromosome. Erasure of its imprinting results in RasGrf1 downregulation and has been demonstrated in a population of pluripotent adult tissues-derived very small embryonic like stem cells (VSELs), stem cells involved in...

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PMID: 21765200
DOI: 10.18632/aging.100354

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