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Fetal Leydig cells dedifferentiate and serve as adult Leydig stem cells

1 Dec 2018

Abstract excerpt

ABSTRACT Previous studies have established that fetal Leydig cells (FLCs) and adult Leydig cells (ALCs) show distinct functional characteristics. However, the lineage relationship between FLCs and ALCs has not been clarified yet. Here, we reveal that a subset of FLCs dedifferentiate at fetal stages to give rise to ALCs at the pubertal stage. Moreover, the dedifferentiated cells contribute to the peritubular myoid...

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PMID: 30518625
DOI: 10.1242/dev.169136

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