Article
Control of mitotic spindle angle by the RAS-regulated ERK1/2 pathway determines lung tube shape.
Science (New York, N.Y.) - 15 Jul 2011
Tang Nan, Marshall Wallace F, McMahon Martin, Metzger Ross J, Martin Gail R
Abstract excerpt
During early lung development, airway tubes change shape. Tube length increases more than circumference as a large proportion of lung epithelial cells divide parallel to the airway longitudinal axis. We show that this bias is lost in mutants with increased extracellular signal-regulated kinase 1...
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