A Genetic Model of Epilepsy with a Partial Alzheimer's Disease-Like Phenotype and Central Insulin Resistance.

doi:10.1007/s12035-022-02810-w

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A Genetic Model of Epilepsy with a Partial Alzheimer's Disease-Like Phenotype and Central Insulin Resistance.

Molecular neurobiology - 1 Jun 2022

Alves Suélen Santos, da Silva Junior Rui Milton Patrício, Delfino-Pereira Polianna, Pereira Marilia Gabriella Alves Goulart, Vasconcelos Israel, Schwaemmle Hanna, Mazzei Rodrigo Focosi, Carlos Maiko Luiz, Espreafico Enilza Maria, Tedesco Antônio Claudio, Sebollela Adriano, Almeida Sebastião Sousa, de Oliveira José Antônio Cortes, Garcia-Cairasco Norberto

Abstract excerpt

Studies have suggested an important connection between epilepsy and Alzheimer's disease (AD), mostly due to the high number of patients diagnosed with AD who develop epileptic seizures later on. However, this link is not well understood. Previous studies from our group have identified memory impairment and metabolic abnormalities in the Wistar audiogenic rat (WAR) strain, a genetic model of epilepsy. Our goal was...

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PMID: 35378696
DOI: 10.1007/s12035-022-02810-w

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