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Article

Epithelial-mesenchymal transition and its implications for fibrosis

15 Dec 2003

Abstract excerpt

Epithelial to mesenchymal transition (EMT) is a central mechanism for diversifying the cells found in complex tissues. This dynamic process helps organize the formation of the body plan, and while EMT is well studied in the context of embryonic development, it also plays a role in the genesis of fibroblasts during organ fibrosis in adult tissues. Emerging evidence from studies of renal fibrosis suggests that more...

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PMID: 14679171
DOI: 10.1172/jci20530

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