Article

Mesenchymal stem cells alleviate epithelial-to-mesenchymal transition by modulating the IRE1α branch of the endoplasmic reticulum stress response

2022-04-13

Abstract excerpt

<h4>Background: </h4> Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial lung disease, and it carries a poor prognosis due to the lack of efficient diagnosis and treatments. Epithelial-mesenchymal transition (EMT) plays a key role in the pathogenesis of IPF. Endoplasmic reticulum (ER) stress contributes to fibrosis via EMT-mediated pathways. Mesenchymal stem cells (MSCs) are a promising...

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Literature Corpus work: edf53bfd-44b3-5924-bc0e-82378ef1e534
DOI: 10.21203/rs.3.rs-1533966/v1

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