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Article

Aberrant DNA methylation but not mutation of CITED4 is associated with alteration of HIF-regulated genes in breast cancer.

Breast cancer research and treatment - 1 Nov 2011

Huang Katie T, Takano Elena A, Mikeska Thomas, Byrne David J, Dobrovic Alexander, Fox Stephen B

Abstract excerpt

CBP/p300-interacting transactivator with ED-rich carboxy-terminal domain 4 (CITED4) inhibits HIF-1α transactivation by binding to CBP/p300. We hypothesised that either somatic mutation or hypermethylation of the CITED4 gene underlies CITED4 down-regulation and thus enhanced HIF-1α expression in some breast tumours. DNA sequencing was used to screen for somatic mutations. Methylation-sensitive high resolution...

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Identifiers

PMID: 21755341
DOI: 10.1007/s10549-011-1657-1

Genes

CITED4
VEGFA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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