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Functional Impact of Chromatin Remodeling Gene Mutations and Predictive Signature for Therapeutic Response in Bladder Cancer

2 Oct 2017

Abstract excerpt

Abstract Urothelial carcinoma accounts for most of the bladder cancer cases. Using next-generation sequencing (NGS) technology, we found that a significant percentage (83%) of tumors had mutations in chromatin-remodeling genes. Here, we examined the functional relevance of mutations in two chromatin-remodeling genes, EP300 and its paralog, CREBBP, which are mutated in almost one-third of patients. Interestingly,...

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Share to Bladder and Urothelial Cancer Treatments
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PMID: 28970362
DOI: 10.1158/1541-7786.mcr-17-0260

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