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Article

Required concentration index quantifies effective drug combinations against hepatitis C virus infection.

Theoretical biology & medical modelling - 9 Jan 2021

Kakizoe Yusuke, Koizumi Yoshiki, Ikoma Yukino, Ohashi Hirofumi, Wakita Takaji, Iwami Shingo, Watashi Koichi

Abstract excerpt

Successful clinical drug development requires rational design of combination treatments based on preclinical data. Anti-hepatitis C virus (HCV) drugs exhibit significant diversity in antiviral effect. Dose-response assessments can be used to determine parameters profiling the diverse antiviral effect during combination treatment. In the current study, a combined experimental and mathematical approaches were used...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33422060
DOI: 10.1186/s12976-020-00135-6
PMCID: PMC7796629

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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