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Article

Optimal drug cocktail design: methods for targeting molecular ensembles and insights from theoretical model systems.

Journal of chemical information and modeling - 1 May 2008

Radhakrishnan Mala L, Tidor Bruce

Abstract excerpt

Drug resistance is a significant obstacle in the effective treatment of diseases with rapidly mutating targets, such as AIDS, malaria, and certain forms of cancer. Such targets are remarkably efficient at exploring the space of functional mutants and at evolving to evade drug binding while still maintaining their biological role. To overcome this challenge, drug regimens must be active against potential target...

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Identifiers

PMID: 18505239
DOI: 10.1021/ci700452r
PMCID: PMC3548403

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