Article

Structural Design of Chimeric Antigens for Multivalent Protein Vaccines

2017-09-11

Abstract excerpt

The development of prophylactic vaccines against pathogenic bacteria is a major objective of the World Health Organisation. However, vaccine development is often hindered by antigenic diversity and the difficulties encountered manufacturing immunogenic membrane proteins. Here, we employed structure-based design as a strategy to develop Ch imeric A ntigens (ChAs) for subunit vaccines. ChAs were generated against...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: be00d877-33ae-5c72-8b0d-f7c66e0ec9d1
DOI: 10.1101/187336

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structural Design of Chimeric Antigens for Multivalent Protein VaccinesDOI 10.1101/187336Read

Structure-based design of chimeric antigens for multivalent protein vaccinesSemantic proximity Read

Rational design of a meningococcal antigen inducing broad protective immunity.Semantic proximity Read

Design and Evaluation of Meningococcal Vaccines through Structure-Based Modification of Host and Pathogen MoleculesSemantic proximity Read

The rational structure-based design of a protein nanoparticle presenting a chimeric MenB antigenSemantic proximity Read

Rationally designed minimized TbpB confers broad protection against meningococcal infectionSemantic proximity Read

Neisseria meningitidis factor H-binding protein fHbp: a key virulence factor and vaccine antigenSemantic proximity Read

Structural and Computational Biology in the Design of Immunogenic Vaccine AntigensSemantic proximity Read

Novel approaches to Neisseria meningitidis vaccine designSemantic proximity Read

Vaccines, reverse vaccinology, and bacterial pathogenesis.Semantic proximity Read

Quest for a broad-range vaccine against Neisseria meningitidis serogroup B: implications of genetic variations of the surface-exposed proteins.Semantic proximity Read

Identification of Vaccine Candidates Against Serogroup B Meningococcus by Whole-Genome SequencingSemantic proximity Read

Broad vaccine coverage predicted for a bivalent recombinant factor H binding protein based vaccine to prevent serogroup B meningococcal diseaseSemantic proximity Read