A Drosophila gene that is homologous to a mammalian gene associated with tumor metastasis codes for a nucleoside diphosphate kinase.

doi:10.1016/0092-8674(90)90496-2

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Article

A Drosophila gene that is homologous to a mammalian gene associated with tumor metastasis codes for a nucleoside diphosphate kinase.

Cell - 30 Nov 1990

Biggs J, Hersperger E, Steeg P S, Liotta L A, Shearn A

Abstract excerpt

The product of the abnormal wing discs (awd) gene of Drosophila is 78% identical to the product of the nm23 gene of mammals, which is differentially expressed in certain metastatic tumors. We present evidence that the awd gene codes for a nucleoside diphosphate kinase (NDP kinase) and that this A...

Topics

Alleles
Amino Acid Sequence
Animals
Antibodies
Cattle
Chromosomes
Cross Reactions
Drosophila
Erythrocytes
Genes
Humans
Larva
Liver
Microtubules
Mitosis
Molecular Sequence Data
Mutation
Neoplasm Metastasis

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