Tumor suppression in Drosophila is causally related to the function of the lethal(2) tumorous imaginal discs gene, a dnaJ homolog.

doi:10.1002/dvg.1020160110

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Article

Tumor suppression in Drosophila is causally related to the function of the lethal(2) tumorous imaginal discs gene, a dnaJ homolog.

Developmental genetics - 1 Jan 1995

Kurzik-Dumke U, Gundacker D, Renthrop M, Gateff E

Abstract excerpt

The Drosophila melanogaster tumor suppressor gene lethal(2)tumorous imaginal discs (l(2)tid) causes in homozygotes malignant growth of cells of the imaginal discs and the death of the mutant larvae at the time of puparium formation. We describe the molecular cloning of the l(2)tid+ gene and its temporal expression pattern in the wild-type and mutant alleles. Germ line rescue of the tumor phenotype was achieved...

Topics

Alleles
Amino Acid Sequence
Animals
Animals, Genetically Modified
Base Sequence
Chromosome Mapping
Cloning, Molecular
DNA, Complementary
Drosophila Proteins
Drosophila melanogaster
Escherichia coli

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Escherichia coli Proteins

Exons

Fungal Proteins

Genes, Insect

Genes, Tumor Suppressor

HSP40 Heat-Shock Proteins

Heat-Shock Proteins

Source

Open in PubMed

Identifiers

PMID: 7758246
DOI: 10.1002/dvg.1020160110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7758246-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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