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Article

The Impact of Drosophila Awd/NME1/2 Levels on Notch and Wg Signaling Pathways.

International journal of molecular sciences - 1 Oct 2020

Serafini Giulia, Giordani Giorgia, Grillini Luca, Andrenacci Davide, Gargiulo Giuseppe, Cavaliere Valeria

Abstract excerpt

Awd, the Drosophila homologue of NME1/2 metastasis suppressors, plays key roles in many signaling pathways. Mosaic analysis of the null awdJ2A4 allele showed that loss of awd gene function blocks Notch signaling and the expression of its target genes including the Wingless (Wg/Wnt1) morphogen. We also showed that RNA interference (RNAi)-mediated awd silencing (awdi) in larval wing disc leads to chromosomal...

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Identifiers

PMID: 33019537
DOI: 10.3390/ijms21197257
PMCID: PMC7582475

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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