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Article

Genetic variants in ERCC1 and XPC predict survival outcome of non-small cell lung cancer patients treated with platinum-based therapy.

Scientific reports - 6 Sept 2017

Zhang Ruoxin, Jia Ming, Xue Huijing, Xu Yuan, Wang Mengyun, Zhu Meiling, Sun Menghong, Chang Jianhua, Wei Qingyi

Abstract excerpt

Nucleotide excision repair (NER) plays a vital role in platinum-induced DNA damage during chemotherapy. We hypothesize that regulatory single nucleotide polymorphisms (rSNPs) of the core NER genes modulate clinical outcome of patients with advanced non-small cell lung cancer (NSCLC) treated with platinum-based chemotherapy (PBS). We investigated associations of 25 rSNPs in eight NER genes with progression free...

Topics

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Antineoplastic Combined Chemotherapy Protocols
Carcinoma, Non-Small-Cell Lung
Disease Progression
Endonucleases
Kaplan-Meier Estimate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Grading

Neoplasm Metastasis

Neoplasm Staging

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Identifiers

PMID: 28878296
DOI: 10.1038/s41598-017-10800-5
PMCID: PMC5587538

Genes

XPC
ERCC1
ERCC4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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