Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variants in nucleotide excision repair pathway predict survival of esophageal squamous cell cancer patients receiving platinum-based chemotherapy.

Molecular carcinogenesis - 1 Nov 2018

Zhang Ruoxin, Zhou Fei, Cheng Lei, Yu Alexandria, Zhu Meiling, Wang Mengyun, Zhang Zhuanxu, Xiang Jiaqing, Wei Qingyi

Abstract excerpt

The benefits of platinum-based chemotherapy (PBC) on survival of esophageal squamous cell carcinoma (ESCC) patients are inexplicit due to the varied therapeutic effects. Nucleotide excision repair (NER) pathway plays a vital role in removing platinum-DNA adducts in tumor cells and hence may modulate the therapeutic effect and survival outcome. The present study assessed the associations of 26 potentially...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Combined Chemotherapy Protocols
Share to DNA Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Esophageal Squamous Cell Carcinoma

Share to Kaplan-Meier Estimate

Share to Linkage Disequilibrium

Share to Neoplasm Metastasis

Share to Neoplasm Staging

Share to Platinum

Source

Identifiers

PMID: 30035334
DOI: 10.1002/mc.22877

Genes

ERCC2
ERCC5
HRG
XPC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variants in nucleotide excision repair pathway predict survival of esophageal squamous cell cancer patients receiving platinum-based chemotherapy.PMID 30035334Read ↗

Genetic variants of DNA repair genes predict the survival of patients with esophageal squamous cell cancer receiving platinum-based adjuvant chemotherapy.Semantic proximity Read ↗

Genetic variants in ERCC1 and XPC predict survival outcome of non-small cell lung cancer patients treated with platinum-based therapy.Semantic proximity Read ↗

An ERCC4 regulatory variant predicts grade-3 or -4 toxicities in patients with advanced non-small cell lung cancer treated by platinum-based therapy.Semantic proximity Read ↗

Single nucleotide polymorphisms of nucleotide excision repair pathway are significantly associated with outcomes of platinum-based chemotherapy in lung cancer.Semantic proximity Read ↗

ERCC1 single nucleotide polymorphism C8092A, but not its expression is associated with survival of esophageal squamous cell carcinoma patients from Fujian province, China.Semantic proximity Read ↗

Role of ERCC5 promoter polymorphisms in response to platinum-based chemotherapy in patients with advanced non-small-cell lung cancer.Semantic proximity Read ↗

Genetic signatures of ERCC1 and ERCC2 expression, along with SNPs variants, unveil favorable prognosis in SCLC patients undergoing platinum-based chemotherapy.Semantic proximity Read ↗

Polymorphisms of multiple genes involved in NER pathway predict prognosis of gastric cancer.Semantic proximity Read ↗

Nucleotide excision repair pathway gene polymorphisms are associated with risk and prognosis of colorectal cancer.Semantic proximity Read ↗

Combined effect of ERCC1 and ERCC2 polymorphisms on overall survival in non-squamous non-small-cell lung cancer patients treated with first-line pemetrexed/platinum.Semantic proximity Read ↗

Identification of genetic variants in base excision repair pathway and their associations with risk of esophageal squamous cell carcinoma.Semantic proximity Read ↗

Association of single nucleotide polymorphisms in ERCC2 gene and their haplotypes with esophageal squamous cell carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.