Article
Single nucleotide polypmorphisms in ERCC1 are associated with disease progression, and survival in patients with advanced stage ovarian and primary peritoneal carcinoma; a Gynecologic Oncology Group study.
Gynecologic oncology - 1 Jul 2011
Krivak Thomas C, Darcy Kathleen M, Tian Chunqiao, Bookman Michael, Gallion Holly, Ambrosone Christine B, Deloia Julie A
Abstract excerpt
OBJECTIVE: This study evaluated common polymorphisms in excision repair cross-complementation group 1 (ERCC1) involved in repair of platinum-induced DNA damage in advanced-stage, epithelial ovarian/peritoneal/tubal cancer (EOC/PPC/FTC) patients treated with intravenous carboplatin- and paclitaxel-based chemotherapy. METHODS: Pyrosequencing was performed to examine single nucleotide polymorphisms (SNPs) in codon...
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