Article
Identification of 11-amino acid peptides that disrupt Notch-mediated processes in Drosophila.
Journal of biomedical science - 17 Jun 2011
Pi Haiwei, Huang Yi-Chun, Chen I-Chun, Lin Chung-De, Yeh Hsiao-Fong, Pai Li-Mei
Abstract excerpt
BACKGROUND: The conserved Notch signaling pathway regulates cell fate decisions and maintains stem cells in multicellular organisms. Up-regulation of Notch signaling is observed in several types of cancer and is causally involved in proliferation and survival of cancer cells. Thus, it is of great...
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