Confirmation of TNIP1 but not RHOB and PSORS1C1 as systemic sclerosis risk factors in a large independent replication study.

doi:10.1136/annrheumdis-2012-201888

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Article

Confirmation of TNIP1 but not RHOB and PSORS1C1 as systemic sclerosis risk factors in a large independent replication study.

Annals of the rheumatic diseases - 1 Apr 2013

Bossini-Castillo Lara, Martin Jose Ezequiel, Broen Jasper, Simeon Carmen P, Beretta Lorenzo, Gorlova Olga Y, Vonk Madelon C, Ortego-Centeno Norberto, Espinosa Gerard, Carreira Patricia, García de la Peña Paloma, Oreiro Natividad, Román-Ivorra José Andrés, Castillo María Jesús, González-Gay Miguel A, Sáez-Comet Luis, Castellví Ivan, Schuerwegh Annemie J, Voskuyl Alexandre E, Hoffmann-Vold Anna-Maria, Hesselstrand Roger, Nordin Annika, Lunardi Claudio, Scorza Raffaella, van Laar Jacob M, Shiels Paul G, Herrick Ariane, Worthington Jane, Fonseca Carmen, Denton Christopher, Tan Filemon K, Arnett Frank C, Assassi Shervin, Koeleman Bobby P, Mayes Maureen D, Radstake Timothy R D J, Martin Javier

Abstract excerpt

INTRODUCTION: A recent genome-wide association study in European systemic sclerosis (SSc) patients identified three loci (PSORS1C1, TNIP1 and RHOB) as novel genetic risk factors for the disease. The aim of this study was to replicate the previously mentioned findings in a large multicentre indepe...

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Identifiers

PMID: 22896740
DOI: 10.1136/annrheumdis-2012-201888
PMCID: PMC3887516

Genes

TNIP1
RHOB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22896740-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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