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Genome-wide mapping of imprinted differentially methylated regions by DNA methylation profiling of human placentas from triploidies

13 Jul 2011

Abstract excerpt

BACKGROUND: Genomic imprinting is an important epigenetic process involved in regulating placental and foetal growth. Imprinted genes are typically associated with differentially methylated regions (DMRs) whereby one of the two alleles is DNA methylated depending on the parent of origin. Identifying imprinted DMRs in humans is complicated by species- and tissue-specific differences in imprinting status and the...

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PMID: 21749726
DOI: 10.1186/1756-8935-4-10

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