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Article

Multilocus methylation defects in imprinting disorders

12 Jan 2015

Abstract excerpt

Mammals inherit two complete sets of chromosomes, one from the father and one from the mother, and most autosomal genes are expressed from both maternal and paternal alleles. In imprinted genes, the expression of the allele is dependent upon its parental origin. Appropriate regulation of imprinted genes is important for normal development, with several genetic diseases associated with imprinting defects. A common...

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Share to Epigenetics and DNA Methylation
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PMID: 25581766
DOI: 10.1515/bmc-2014-0037

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