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Hydatidiform mole and triploidy: the role of genomic imprinting in placental development

28 Jan 2005

Abstract excerpt

Genomic imprinting, the differential expression of paternal and maternal alleles, is involved in the regulation of embryonic and fetal growth and development. In this review, we focus on the genetics of a disorder caused by a global defect in genomic imprinting, the hydatidiform mole. The ratio between the maternal and paternal genomes is critical in determining the development of both the embryonic and...

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PMID: 15677707
DOI: 10.1093/humupd/dmh060

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