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Article

Substance P signaling mediates BMP-dependent heterotopic ossification

11 Jul 2011

Abstract excerpt

Heterotopic ossification (HO) is a disabling condition associated with neurologic injury, inflammation, and overactive bone morphogenetic protein (BMP) signaling. The inductive factors involved in lesion formation are unknown. We found that the expression of the neuro-inflammatory factor Substance P (SP) is dramatically increased in early lesional tissue in patients who have either fibrodysplasia ossificans...

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PMID: 21748788
DOI: 10.1002/jcb.23259

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